SCP-500 is a small plastic can which contains forty-seven (47) red pills. One pill, when taken orally, effectively cures the subject of all diseases within two hours, exact time depending on the severity and amount of the subject's conditions. Despite extensive trials, all attempts at synthesizing more of what is thought to be the active ingredient of the pills have been unsuccessful. SCP-500 has been recorded to cure SCP-008 and the effects of SCP-439, and SCP-409.
SCP-500 pills can be found near deceased guards, SCP-035's containment chamber, or the small room in the Maintenance Tunnels. SCP-500 can cure the illnesses caused by the SCP's mentioned above, SCP-1025, and any injuries the player has attained. Because of the small amount of SCP-500 pills that can be found in the facility, it is advised that SCP-500 should not be used unless the player's condition is critical.
If one of the SCP-500 pills is put into SCP-914 on the "Fine" setting, it will create SCP-427. However If one of the SCP-500 pills is put into SCP-914 on the "Very Fine" setting, it will create a lethal "Upgraded pill" that if consumed causes blurred vision, brownish drippings as well as a message saying "Your muscles are swelling.". After 30 seconds, the player is forced into a crouching position with a message saying "You can't feel your legs. But you don't need legs anymore". After a few seconds player dies, displaying a unique death message that says "Requesting support from MTF Nu-7. We need more firepower to take this thing down.". This is similar to the effects of prolonged wear of SCP-427.
- In the inventory, SCP-500 is fully red. However, when not in the inventory, it is both white and red. This is likely an oversight.
- SCP-500, like SCP-008, was originally part of a third-party mod for SCP - Containment Breach made by forum user InnocentSam. After the game's creator Joonas Rikkonen Regalis played the mod, both were added into the game in the version 0.7 update.
- When SCP-500 was first added to the Foundation's SCP series in 2008, there were originally 59 pills in containment. The current number of pills currently stands at 47 due to 12 of them being used for various testing purposes.